LSU has a massive matchup against Ole Miss on the docket for Week 5. The third-ranked Tigers travel to Oxford to take on the 13th-ranked Ole Miss Rebels on Saturday afternoon. Both teams cruised to victories in Week 4, but they faced very different opponents. LSU defeated FCS Southeastern Louisiana 56-10 in a glorified scrimmage, while Ole Miss defeated Tulane, one of the best teams in a non-power conference, by a score of 45-10.
The Magnolia Bowl is one of the most anticipated games on the college football schedule every year, and this year's matchup is no different. LSU and Ole Miss are both off to 4-0 starts, giving this rivalry matchup a little extra juice. Kick-off is now less than a week away, and LSU vs Ole Miss betting odds are now available. Who has the edge?
LSU vs Ole Miss early betting odds
Oddsmakers are expecting a closely-contested battle, and the game is essentially a toss up. But, oddsmakers are giving the edge to Ole Miss by the slightest of margins. As of 8:30 a.m. CT on Sunday, September 21, Ole Miss is favored by 1.5 points on FanDuel Sportsbook. When it comes to the moneyline, Ole Miss has odds of -115 and LSU has odds of -104. That's about as close as it can get. The total, or over/under, is listed at 54.5.
Spread
- LSU +1.5 (-114)
- Ole Miss -1.5 (-106)
Moneyline
- LSU (-104)
- Ole Miss (-115)
Total
- Over 54.5 (-106)
- Under 54.5 (-114)
So far this season, LSU is 4-0 overall and 2-2 against the spread. The Tigers have covered the spread against Clemson and Florida, but failed to cover against Louisiana Tech and Southeastern Louisiana. The under is 3-1 for LSU so far this season. LSU's Week 4 matchup vs SELU was the first game to go over the total for LSU in 2025.
On the other side, Ole Miss is 4-0 and 3-1 against the spread. In their most recent game, the Rebels defeated the Green Wave by 35 points after closing as 11.5-point favorites. The over is 3-1 for Ole Miss so far this season, with the Tulane game being the lone contest to stay under the total for Lane Kiffin's squad.
The Tigers and Rebels first met way back in 1894, and have played each other every year since 1945. The last two editions of this rivalry have resulted in wild back-and-forth games. Two years ago in 2023, Ole Miss won by a score of 55-49 in game that came down to the final play of regulation. LSU got revenge last year in Baton Rouge with a 29-26 victory in overtime despite never holding a lead in regulation. What will this year's matchup have in store?